drug-related damage of the ageing gastrointestinal tract anatomy

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gastrointestinal tract hormones produced by hypothalamus

Digestion - Wikipedia
Digestion - Wikipedia
Digestion is the breakdown of large insoluble food molecules into small water-soluble food molecules so that they can be absorbed into the watery blood plasma.

All members of the glycoprotein family transduce their intracellular effects via their respective receptors and the associated G-protein, adenylate cyclase, second-messenger systems. CCK1 (CCK derived from N-terminal end of pancreatic colipase; pentapeptide human enterostatin contains the sequence: APGPR regulates fat intake; peripheral or central administration inhibits consumption of a high-fat diet but not a low-fat diet of growth factors; expression of FGF19 gene activated by transcription factor , FXR is activated when ileal enterocytes absorb bile acids, when released to the portal circulation FGF19 stimulates hepatic glycogen and protein synthesis while inhibiting glucose production; reduces the expression and activity of CYP7A1 which is the rate-limiting enzyme in ; acts in the gallbladder to induce relaxation and refilling with bile acids gastric acid and pepsin secretion; exists in two major forms: little gastrin (17 amino acids) and big gastrin (34 amino acids), both result from a single precursor protein of 101 amino acid; both species contain a Y residue in the C-terminal portion of the protein that may be either sulfated (gastrin II) or nonsulfated (gastrin I); both forms bind to the CCK2 (CCK ) receptor on stomach and gut parietal cells with an affinity equal to that of CCK; the C-terminal tetrapeptide of both gastrins and CCK are identical and possess all the biological activities of both gastrin and CCK Gastrin-releasing peptide (GRP), is a bombesin-related peptide; also called neuromedin B released from vagal nerve; stimulates release of gastrin from G cells of the stomach and CCK from small intestinal enteroendocrine I cells primary site is X/A-like enteroendocrine cells of the stomach oxyntic (acid secreting) glands, minor synthesis in intestine, pancreas and hypothalamus regulation of appetite (increases desire for food intake); energy homeostasis; glucose metabolism; gastric secretion and emptying, insulin secretion potentiates glucose-dependent insulin secretion; inhibits glucagon secretion; inhibits gastric emptying enhances digestion and food absorption; inhibits gastric secretions; promotes intestinal mucosal growth initiates inter-digestive intestinal motility; stimulates release of PP; stimulates gallbladder contractions enteroendocrine N cells along the small intestine and proximal large intestine; also in hypothalamus a 13-amino acid peptide derived from a precursor that also produces neuromedin; involved in satiety responses and slows gastric emptying; also involved in nociception (sensation of pain) derived from pro-ghrelin protein; acts in opposition to ghrelin action on appetite contains all of the amino acids of glucagon (see Figure below); inhibits meal-stimulated gastric acid secretion similar to GLP-1 and GLP-2 action; induces satiety, decreases weight gain, and increases energy consumption; has weak affinity for GLP-1 receptor as well as the glucagon receptor, may mimic glucagon actions in liver and pancreas reduced gut motility; delays in gastric emptying, and an inhibition of gallbladder contraction; exerts effects on satiety via actions in the hypothalamus enteroendocrine S cells of the duodenum and to a lesser extent the jejunum pancreatic bicarbonate secretion; inhibits gastric secretions; stimulates PP secretion made by D cells of the gut and δ-cells of the pancreas, also produced in hypothalamus and other organ systems inhibits release and action of numerous gut peptides, e. The various nuclei of the hypothalamus constitute the functional domains of the various hypothalamic areas.

The hCS gene is found in the human growth hormone/human chorionic somatomammotropin (GH/CS) gene cluster as described above in the Growth Hormone section. The activation of adenylate cyclase leads to cAMP production in the cytosol and to the activation of PKA, followed by regulatory phosphorylation of numerous enzymes. The other primary action of oxytocin is the stimulation of uterine smooth muscle contraction leading to childbirth. Unlike renin which has a single substrate, ACE exhibits activity to a wide range of substrates ranging in size from tripeptides to proteins of 42 amino acids. Although the PRL gene is thought to have evolved from an ancestral hormone gene common to GH and hCS, prolactin only shares 16% amino acid homology to these other two hormones.



Glossary | Linus Pauling Institute | Oregon State University
C-reactive protein (CRP) a protein that is produced in the liver in response to inflammation. CRP is a biomarker of inflammation that is strongly associated with the ... gastrointestinal tract hormones produced by hypothalamus Endocrine System - InnerBodyThe endocrine system includes all of the glands of the body and the hormones produced by those glands. The glands are controlled directly by stimulation from the ...

The natriuretic peptide receptors are members of the larger family of single transmembrane spanning. Expression of the NPPB gene occurs primarily in cardiac ventricular myocytes. Although the acronym BNP is still commonly used, the protein is now known as B-type natriuretic peptide or also ventricular natriuretic peptide (but still with the BNP acronym) since it is secreted by cardiac ventricular myocytes.

Peptide Hormones - The Medical Biochemistry PageThe peptide hormones page provides an overview of structure and function of numerous classes of protein-derived hormones which exert a wide-range of autocrine ...
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