drug-related damage of the ageing gastrointestinal tract anatomy

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April 2018 medications requiring prior authorization for
April 2018 medications requiring prior authorization for
April 2018 Medications Requiring Prior Authorization for Medical Necessity Below is a list of medicines by drug class that will not be covered without a prior authorization for medical necessity.

Possibly Porphyrinogenic Major metab by CYP3A4, less by CYP2C9; weak inhibitors of both (Drug Metab Disp 36:986,2008). Minimally to modestly transactivates pregnane X receptor; inhibits CYP (Williams DA. Possibly Porphyrinogenic; insufficient data on metabolism but no indications for P450 interaction in vivo.

Transactivates pregnane X receptor & induces CYP3A4 in several studies, but not in one study (Williams DA. Use with Caution Probably not metab by CYPs PV Tishler MD clinical data: Safe (Drug Metab Disp 33:1567,2005) www. Safe ~85% nonmetab by CYP, with minor contribution of CYP3A4/5 (Clin Pharmacokinet 46:13,2007; Therapeutic Drug Monitor 26:600,2004) www. Minimal transactivation of pregnane X receptor (Clin Pharmacol Therap 80:565,2006; Curr Drug Metab 7:375,2006) Readily absorbed by liver. Opioid derivative metabolised by a series of CYPs, mainly 3A4.



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