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Cymbalta (Duloxetine Hcl): Side Effects, Interactions ...
Cymbalta (Duloxetine Hcl): Side Effects, Interactions ...
Learn about Cymbalta (Duloxetine Hcl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.

The risk of blood pressure decreases may be greater in patients taking concomitant medications that induce orthostatic hypotension (such as antihypertensives) or are potent CYP1A2 inhibitors [see ] and in patients taking CYMBALTA at doses above 60 mg daily. Begin treatment at 30 mg for one week, to allow patients to adjust to the medication before increasing to 60 mg once daily. The interaction between duloxetine and other highly protein bound drugs has not been fully evaluated.

John’s Wort is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases. The risk of falling appears to be related to the degree of orthostatic decrease in blood pressure as well as other factors that may increase the underlying risk of falls. While a 120 mg/day dose was shown to be effective, there is no evidence that doses greater than 60 mg/day confer any additional benefits. Blood pressure should be measured prior to initiating treatment and periodically measured throughout treatment [see Co-administration of CYMBALTA with potent CYP1A2 inhibitors should be avoided [see Because CYP2D6 is involved in CYMBALTA metabolism, concomitant use of CYMBALTA with potent inhibitors of CYP2D6 would be expected to, and does, result in higher concentrations (on average of 60%) of CYMBALTA [see Co-administration of CYMBALTA with drugs that are extensively metabolized by CYP2D6 and that have a narrow therapeutic index, including certain antidepressants (tricyclic antidepressants [TCAs], such as nortriptyline, , and imipramine), phenothiazines and Type 1C antiarrhythmics (e. Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and , which may lead to falls.



Cymbalta Side Effects in Detail - Drugs.com
Learn about the potential side effects of Cymbalta (duloxetine). Includes common and rare side effects information for consumers and healthcare professionals. side effects of cymbalta generic available Cymbalta Uses, Dosage, Side Effects & Warnings - Drugs.comCymbalta (duloxetine) is used to treat major depressive disorder, general anxiety disorder and fibromyalgia. Includes Cymbalta side effects, interactions and indications. Common Side Effects of Cymbalta (Duloxetine Hcl ... - RxListFind a comprehensive guide to possible side effects including common and rare side effects when taking Cymbalta (Duloxetine Hcl) for healthcare professionals and ...
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